Devil May Cry Mission 2: Home Truths contains 9 Lost Souls to be collected. Within this mission you can collect five Lost Souls during your first run-through of the game, while the next four you can collect upon receiving particular weapon or ability from missions that follow mission 2.
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LOST SOUL no. 1
Required ability/weapon: Ophion Angel Lift (ability, unlocked in mission 2)
At the very start of this mission, turn left, jump into the hole, go ahead a bit, and look right. You will see blue spot on a rock. With Ophion Angel Lift that you get during mission 2, you can pull yourself up, and get the Lost Soul.
Entrance at the left.
Ophion Angel Lift can only make you get up.
LOST SOUL no. 2
Required ability/weapon: Aquila (weapon, unlocked in mission 10), Angel Boost (ability, unlocked in mission 3)
Near the first Divinity Statue you can notice a gap between your platform and the blue vine covered entrance to the other room. Brake the blue vines with Aquila weapon from mission 10 and Angel Boost over the gap to get to room with Lost Soul in it.
First Divinity Statue.
Lost Soul behind blue vines.
LOST SOUL no. 3
Required ability/weapon: none
Soon after the room with Sparda portrait on a wall you will find that the nearby passage opened. Lost Soul can be found on a wall, at a platform, after a gap. In order to jump onto the platform with the Lost Soul, use double jump and dodge ability in the air. If you are having problems with jumping on it, return after mission 3, and use the ability Angel Boost to get to it.
Passage that opens near Sparda portrait.
If you fall down, restart from previous checkpoint if you want to save time, getting this Lost Soul.
Lost Soul on other side of platform.
LOST SOUL no. 4
Required ability/weapon: None
Soon after the room with Sparda portrait on a wall, you will find that the nearby passage opened. Lost Soul can be found when you jump in a hole in order to proceed with the mission. It will be on one of the walls.
Lost Soul in a hole.
LOST SOUL no. 5
Required ability/weapon: None
After following two ghost children, and braking down the door they went through, Lost Soul will be above, inside of the next passageway.
Follow children through this door.
Lost Soul above door entrance.
LOST SOUL no. 6
Required ability/weapon: Osiris (weapon, unlocked in mission 2)
Soon after the previous Lost Soul, you will find a blue vine covered entrance to the room where the next Lost Soul is. Only way to make your way through the blue vines is by destroying them with the Osiris weapon.
Lost Soul hidden behind blue vine entrance.
LOST SOUL no. 7
Required ability/weapon: None
After the first dream you have jump into a hole in the ground, enter the next passageway and look up. There will be a Lost Soul above the door entrance.
Jump down.
Lost Soul is in next passage.
Above the door entrance.
LOST SOUL no. 8
Required ability/weapon: Osiris (weapon, unlocked in mission 2)
After following the ghost of your mother, you will find next Divinity Statue. Close to this Statue is a blue vine door. Since you acquire Osiris soon after this section just turn back and collect this Lost Soul (it is above the entrance).
Follow the ghost of your mother.
Second Divinity Statue.
Blue vine entrance.
Lost Soul above door entrance.
LOST SOUL no. 9
Required ability/weapon: Angel Boost (ability, unlocked in mission 3)
Following the ghost of your mother will make you jump over platforms. Upon entering one part of the house you will notice, to your right, a road to a room where the last Lost Soul can be found. Since there is big gap between, you will need to come back here after mission 3 and after you acquire the Angel Boost ability, that can help you jump over that gap.